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     Pure Theacrine Capsules ・ Energy Boosting Supplement

Theacrine is a potent energy boosting supplement that has been proven to be superior to caffeine.

  • Enhances energy and mood.
  • No tolerance - Even after weeks of use Theacrine remains effective.
  • Improves concentration and the ability to focus.
  • Improves motivation and the will to exercise.
  • Just as safe as caffeine.
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Proven Safe and Effective

Theacrine is a potent energy boosting supplement related to caffeine but more effective and non-habit forming. It is non-toxic and has few side effects when used as recommended.

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Before switching to theacrine I was a coffee addict for years, drinking as many as 4 cups per day. Theacrine provides the same boost, but doesn't stop being effective as quickly as caffeine. Now I don't need coffee to function, and get a nice boost when I do have a cup!

Lisa N

Theacrine is great! I like to take it every other day before I hit the gym. It gives me the boost I need to have great workouts.

James P

Theacrine has the energy boosting effects similar to caffeine without the jitters, the crash and the habituation that often accompanies caffeine. While caffeine can be great on its own, theacrine (as TeaCrine®) is reported to take caffeine to a new level of energy and focus.

What is Theacrine? Is it a Nootropic?

Theacrine is a purine alkaloid similar in structure to caffeine. However, theacrine’s effects are very different from caffeine. The camellia assamica plant, in particular the kucha variant has the highest natural levels of theacrine. Kucha tea has been made from this plant and used by humans for centuries, but only recently have studies identified the wide array or benefits from theacrine use.

Like caffeine, theacrine inhibits adenosine receptors. What sets it apart from caffeine is that it also boosts dopamine production.* Theacrine’s dopaminergic action improves mood, concentration, the “reward center” in the brain, and (in some cases) may improve libido.* Theacrine is a nootropic, and highly sought after by “biohackers” seeking to maximize cognitive performance.

Perhaps the most interesting theacrine attribute is its lack of tolerance buildup that is all too common with caffeine. One study at a major U.S. university involving 60 subjects found no signs of a tolerance after eight weeks of daily use (note: doses were 200mg and 300mg per day). The absence of a tolerance buildup and the dopamine boost are two of the biggest advantages of using theacrine over caffeine, or in combination with caffeine. Theacrine’s energy boosting benefits anecdotally appear to remain effective for approximately five hours--much longer than caffeine. The only branded and trusted form of theacrine--TeaCrine®-- will seek to answer whether using theacrine in combination with caffeine can delay or eliminate the tolerance to caffeine.

Why Theacrine?

  • Theacrine (as TeaCrine®) reduces fatigue and increases mental and physical energy*
  • Improves mood and motivation*
  • Improves concentration and the ability to focus*
  • Can aid in reducing anxiety, while improving energy levels*
  • No rapid tolerance (like caffeine) to theacrine (as TeaCrine®)*

Theacrine (as TeaCrine®) Energy and Cognitive Benefits:

Theacrine is ideal for demanding athletes, bodybuilders, “biohackers,” gamers and driven professionals who strive to attain peak performance cognitively and physically. As mentioned earlier, theacrine’s effects come from the synergistic reactions between two neural pathways: dopaminergic and adenosinergic pathways. Based on preclinical and human clinical research, theacrine (as TeaCrine®) enhances the mind/muscle connection, which facilitates a wide range of healthy functions such as:

  • Supporting energy production*
  • Supporting positive mood*
  • Increasing motivation to exercise*
  • Increasing neural drive*

Studies on TheaCrine (as TeaCrine®)


The effects of theacrine (as TeaCrine®), a nature-identical purine alkaloid, were tested for subjective measures of cognitive function, psychometric and hemodynamic (blood pressure) indices in healthy humans in both preclinical and human clinical studies.*

Over a 3-hour period, two human clinical pilot trials with healthy participants showed significant:

  • Increase in energy
  • Decrease in feelings of fatigue
  • Increase in mental energy

The study also gathered data on safety and tolerance biomarkers, including heart rate and blood pressure. The second study revealed similar results to the first study while indicating that larger doses were not needed for optimal effects. In fact, the following study results show participants received benefits at a relatively low dose (200 mg).


In a 60-subject, placebo-controlled study over 8 weeks of continuous, daily use, theacrine (as TeaCrine®) was found to be as safe as the placebo for standard measures of safety. Just as importantly, the ingredient showed no signs of habituation or tolerance.

The first of its kind, this study set out to determine the safety and tachyphylactic (habituation) effect of theacrine (as TeaCrine®) supplementation in humans. The main findings of low- and high-dose (200mg and 300mg) theacrine (as TeaCrine®) supplementation included the following:

  1. Supplementation was safe and did not alter hemodynamic (blood pressure) measures or blood measures associated with clinical safety (routine blood work).
  2. There was no evidence of a tachyphylactic/habituation response that is typical of neuroactive agents such as caffeine and other stimulants.


In another 2015 study performed in mice, results of behavioral tests suggested that oral administration of theacrine significantly reversed learning and memory impairment caused by central fatigue. In addition, levels of fatigue-related neurotransmitters in the brains of restraint mice, including 5-hydroxytryptamine (related to serotonin) and dopamine as well as their metabolites, were restored by theacrine.

Does Theacrine Have Any Side Effects?

When used at dosages up to 300mg, there are no known side effects using the TeaCrine® brand of theacrine. It is possible that some of the same side effects associated with caffeine and similar stimulants may be experienced at higher doses.

Who is Using Theacrine?

Because of theacrine’s (as TeaCrine®) unique safety profile, many people are able to benefit from it. They include:

  • Demanding athletes
  • Bodybuilders
  • “Biohackers”
  • Gamers
  • Energy drink users
  • Driven professionals

How Should Theacrine be Used?

Theacrine is most commonly used to provide a boost in energy and/or focus. If being used for that purpose, a dose of 25-150 mg is typically sufficient in combination with caffeine. Used alone, theacrine is best at a dose around 200mg. Theacrine (as TeaCrine®) has been studied at doses up to 400 mg, but the biggest “bang for the buck” (based on evidence to date) is no higher than 200mg.

Theacrine can be used in combination with caffeine and/or acetylcholine donors like choline bitartrate, alpha glycerophosphacholine, citicoline, huperzine A and DMAE. When used without caffeine, it can be consumed anytime--including evening for “PM Energy”--without negatively impacting sleep. More evidence is needed to uncover how theacrine may complement other ingredients such as theanine, bacopa monieri, taurine, ashwagandha and more.

How Does Theacrine Differ From Caffeine?

Theacrine (as TeaCrine®) has energy boosting effects similar to caffeine without the jitters, crash, and habituation that often accompanies caffeine. The energy boosting effects of theacrine have been experienced to last hours. While theacrine is very similar in molecular structure to caffeine, it is very different when it comes to actions.

Tolerance to caffeine builds much more quickly than to theacrine. A caffeine tolerance can form in four to five days, while a 60-subject human clinical study on theacrine (as TeaCrine®) showed daily use for eight weeks without any tolerance forming. Theacrine produces consistent results every time.

Theacrine doesn’t lead to a crash or sleeplessness. While people enjoy the energy boosting effects of caffeine, the substance is often associated with an unpleasant "crash" wherein energy fades and mood falls. Caffeine’s stimulating properties can also make it difficult to rest following a workout or to fall asleep. Theacrine’s unique mechanisms of action do not lead to the same energy and mood crash or cause the same difficulties falling asleep.*

Theacrine doesn’t lead to jitters: Athletes can take TeaCrine® as a pre-workout energy booster and return to a state of calm rest afterward, without the jitters and restlessness related to caffeinated pre-workout stimulants. The energy lasts for hours, which can be particularly suitable for athletes competing in longer events such as baseball, soccer, hockey, golf and many more. This gentler action makes theacrine a unique option for anyone looking for a safe energy source with no known negative side effects. Theacrine (as TeaCrine®) is free of WADA-banned substances and certified by Informed Choice and Informed Sport.

Combining theacrine with caffeine is complementary; many report a synergism between the two. When combined, theacrine is reported to potentiate, enhance and extend the efficacy of caffeine.* Commonly observed effects also show that it can help minimize the limitations of high-dose and chronic caffeine use.

In addition to the differences outlined above, theacrine can help consumers throttle up or down as needed (autoregulate), delivering a smooth lift that's not followed by a crash.* This “lift” has been described as a smooth increase in energy, clean focus, enhanced concentration and drive by early adopters of theacrine (as TeaCrine®).*

What is TeaCrine® (as TeaCrine®) and How Is It Different?

TeaCrine® is a pure, patented theacrine that consumers can trust.

  1. With the first in-human research and studies, TeaCrine® is the only source for claims and validated efficacy.
  2. TeaCrine® has the only validated reference standard and assay method proving that TeaCrine is pure theacrine.
  3. TeaCrine® is the only theacrine with Informed Sport and Informed Choice certification so competitive athletes can use TeaCrine with peace of mind.
  4. TeaCrine® is the first and only theacrine that has scaled up to mass production in an NSF-certified, GMP factory. No one else in the world can supply large volumes with TeaCrine’s® quality and cost advantage.
  5. TeaCrine® has the world’s only long-term safety data in both humans and rats.
  6. TeaCrine® has an established research program, with further clinical trials in 2015 and 2016.
  7. The “TeaCrine®” brand is a strong, global brand building in popularity in the energy and cognitive sectors.
  8. TeaCrine® is self-affirmed Generally Recognized As Safe (self-GRAS) as of December 2015.
  9. TeaCrine® is patent-pending globally through the USPTO and PCT (Patent Cooperation Treaty).
  10. TeaCrine® is trademarked in countries across the globe.
  11. After caffeine, TeaCrine® is currently the best-selling known Informed Choice/Sport approved energy/cognitive ingredient in the world.

Is Theacrine (as TeaCrine®) safe? Is it Informed Choice and/or NCAA and WADA compliant?

TeaCrine®, the patented version of theacrine, is the only self-affirmed Generally Recognized As Safe (GRAS) theacrine. TeaCrine® is also certified by Informed Choice and Informed Sport as being free of banned substances. TeaCrine® is also WADA and NCAA-compliant. Only TeaCrine® has these designations, no other forms of theacrine can make these claims.

The research performed on Theacrine (as TeaCrine®) shows that it is safer than caffeine on an acute (one dose) basis. The LD50 for theacrine (as TeaCrine®) is more than three times higher than caffeine, despite similar use rates On a longer-term basis, a 90-day safety study also showed theacrine (as TeaCrine®) to be far safer than caffeine. One human study in which participants used theacrine (as TeaCrine®) at doses of 200mg and 300mg found no adverse effects and no changes in heart rate or blood pressure during continuous use (i.e. 8 weeks). The body of currently available research for theacrine (as TeaCrine®) suggests no adverse effects when used at similar doses as caffeine—up to about 300mg per day.

Recently there have been more aggressive federal regulators seeking federal prosecutions. The FDA, DOJ, FTC, and even multiple state attorneys general are taking civil and criminal action against companies using various non-DSHEA compliant ingredients that lead to misbranding and adulteration of finished dietary supplement products. These include Picamilon (aka Pikatropin), DMAA and AMP Citrate (DMBA), Acacia Rigidula, Synephrine 30% (warning letter due to a higher % concentrate not being present in the food supply as an article of food in a form that has not been chemically altered/ modified) and others on the watch list include various synthetic HCl PEAs (e.g., BMPEA, N,N-dimethylphenethylamine, N-benzyl-2-PEA, etc. found within other botanical sources), Vinpocetine, and more. Theacrine (as TeaCrine®) is now proven to be the safer alternative to so many questionable products in the marketplace.

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Cited Studies

  1. Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.
  2. Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.
  3. The effects of TeacrineTM, a nature-identical purine alkaloid, on subjective measures of cognitive function, psychometric and hemodynamic indices in healthy humans: a randomized, double-blinded crossover pilot trial
  4. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.
  5. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice.
  6. 1,3,7,9-tetramethyluric acid--a chromosome-damaging agent occurring as a natural metabolite in certain caffeine-producing plants.