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Product Information

Theacrine is a new supplement which boosts mental and physical energy in a manner similar to caffeine, but can be used for longer without a tolerance developing. It is becoming popular as an ingredient in preworkouts due to the boost it provides to stamina, as well as for nootropic purposes due to its ability to improve focus.

Our Theacrine is high quality and is rigorously tested for safety and purity. The Certificate of Analysis for our most current production batch is available here:

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Refund Policy

We stand behind the quality of our product, and therefore offer a full money back guarantee! If you're unhappy with your order let us know within 30 days and we will provide a full refund with no need to return the bottle.

Shipping Information

All orders will be shipped from the United States within 1 - 2 days after being placed. We ship orders via USPS Priority Mail, which takes between 3-7 days for delivery depending on where in the US you are located.

When your order is shipped you will recieve a tracking number so you can track your shipment.

Delivery Guarantee: If your order does not arrive within 15 days of being shipped, we will reship your order free of charge. If it still doesn't arrive, we will give you a complete refund.

What is Theacrine?

Theacrine is a small purine alkaloid molecule which is very similar in structure and effects to caffeine. It most commonly is found in plants that already contain caffeine, and is actually synthesized from the caffeine in these plants. The kucha variant of the camellia assamica plant contains the highest natural quantities of Theacrine, and it is from this plant that Kucha tea is made.

Theacrine has many properties in common with caffeine, including acting as a sedative at low doses and a stimulant at high doses. One key difference in this regard is that the dose at which theacrine acts as a sedative is much higher than the dose at which caffeine does. This is why Kucha tea has a relaxing effect instead of a stimulating one.

Another key difference between caffeine and theacrine is that a tolerance to theacrine builds much more slowly than with caffeine. One study found that over a week of daily theacrine use no tolerance at all was noted. In contrast a tolerance to caffeine begins to develop after just four days. This is a crucial difference between the two molecules which could make theacrine a much more attractive choice for those looking for consistent noticable boosts in energy, rather than just needing a cup of coffee to wake up.

Theacrine's Benefits

Due to it's similar molecular structure and effects profile, Theacrine is commonly compared to caffeine. While more research still needs to be performed, inital results suggest theacrine is superior to caffeine in nearly every aspect. It has a longer half life, appears to be non-habituating, has a positive impact on mood, helps attenuate feelings of stress and irritability, and is less likely to impair sleep.

The most common use of Theacrine is as an alterntive to caffeine due to it's slow developing tolerance. Many longtime coffee drinkers have switched the theacrine to allow their caffeine tolerance to reset while still getting the stimulation they need to go about their day and perform at their best. Theacrine is also synergistic with caffeine, and some like to combine them for an added boost. In a 7-day study on human volunteers, participants who used a moderate dose of 200 mg of theacrine per day reported an improvement in subjective feelings of energy, fatigue, concentration, anxiety, libido, and motivation to exercise. [3] This study also noted an objective improvement in the ability to concentrate of the subjects who used theacrine. (as Teacrine®) [3]

In contrast, when taken at lower doses Theacrine can also be used as a mild sedative. The small doses of 20 - 50 mg found in Kucha tea, for example, are believed to be responsible for it's calming effects. One study found that at low doses Theacrine exhibits both sedative and hypnotic effects. [5]

Research has also shown theacrine to have a number of health benefits aside from its main use as a stimulant. Historically, teas were made from the leaves of Camelia Kuchu (a plant which contains high levels of theacrine) and were used by Chinese rainforest cultures as a pain reliever and anti-inflammatory medicine. It has been theorized that the theacrine in this plant is responsible for these benefits, and the latest research seems to back this up.

One study found that when taken orally at a dose of 8-32 mg/kg theacrine has both an anti-inflammitory and analgesic (pain relieving) effect. [1] One study on rats found a 24.5% - 34.1% increase in latency in a hot-plate test as well as a 10.6% - 18.9% reductions in writhing in an acetic-acid induced writhing test. [1] In contrast, caffeine has neither anti-inflammatory or analgesic properties.

Another study on rats found that theacrine may help reduce the harmfull health effects of a stressful lifestyle. [2] When rats are exposed to long durations of stress caused by being restrained, liver damage is often a consequence of the stress they endure. This study found that when theacrine was administered prior to the stress being induced the resulting liver damage was significantly reduced. [2] If theacrine has a similar benefit in humans, it could help attenuate the health consequences of a stressful lifestyle.

The same study also found that theacrine could potentially reduce liver damage due to oxidative stress. [2] Oxidation is a natural chemical process in the body where molecules lose electrons. This process causes a distrubance in the normal redox state of the cells in which it occurs, and can cause toxic effects through the production of peroxides and free radicals. Our body has methods of preventing this damage, however, and one of the most potent defenses is an antioxidant molecule produced in the liver known as Glutathione.

Studies have found that following a week of Theacrine use, subjects exhibited elevated levels of glutathione in the liver. [2] This suggests that theacrine indirectly works as an antioxidant and reduces tissue damage in the liver due to oxidative stress.

Interest in Theacrine has been building primarilly as an ingredient in preworkout and fat burning supplements due to it's potent stimulant properties. Research has confirmed that it may become very popular in this regard, as one study found that when taken over a 7 day period Theacrine (as Teacrine®) noticably boosted participants' motivation to exercise. [3] Because a tolerance to it builds slower than with Caffeine, athletes will benefit from it for longer before needing to cycle it out.

What is the Recommended Dose?

A dose of between 150 - 300 mg is sufficient to provide a noticable boost in energy and focus. Theacrine is safe to use in higher doses, however doses exceeding 450 mg are not recommended. Care should be used if combining theacrine with caffeine, and lower doses than usual for each should be taken.

There has been little research performed on combining theacrine with other stimulants that are more powerful than caffeine, and doing so is not recommended.

Theacrine's Safety and Side Effects

One study on theacrines acute toxicity found that it's LD50 in rats was 810 mg/kg, this suggests that it is very difficult to overdose on theacrine. [2] Another study found that it's toxicity is similar to caffeine, however. [6] For safety's sake, doses exceeding 500 mg should be avoided until more information becomes available.

A study on humans found that after a week of daily use there were no side effects present and no changes in systemic hemodynamics (blood flow) were noted. [3] Although no "official" side effects were noted in this study, it stands to reason that some of the traditional side effects of overstimulation such as nervousness, anxiety, and jitters would be present at higher doses.

Although theacrine in the form of Kucha tea has been consumed by humans for hundreds of years, and preliminary studies on theacrine suggest it is safe in higher doses of 200 - 450 mg it should be noted that there is still little research on the effects of consuming pure theacrine in humans. That said, all existing evidence points to it's use being as safe or safer than that of caffeine.

How Does Theacrine Work?

Theacrine works in a similar method as caffeine, but has a few key differences. When caffeine is consumed, it blocks receptors for the neuromodulator adenosine. Adensoine is important in many biochemical processes such as energy transfer and signal transmission. Another key role it plays in the body is that of promoting sleep and suppressing arousal. Adenosine provides these sleep promoting effects by binding to adenosine receptors. This binding slows down the activity in the nerve cell, which causes drowsiness.

The structure of caffeine (and theacrine) is very similar to that of adenosine, and when it is present in the brain it fits into the adenosine receptors, preventing adenosine from binding with them. Because caffeine is preventing adenosine from binding with a large number of nerve cells, the cells can no longer indentify its presence. This causes them to speed up instead of slowing down. The nerve cells stimulated in this way also release the hormone epinephrine, which is why the consumption of caffeine increases heart rate and blood pressure.

Caffeine also acts as a dopamine reuptake inhibitor. Dopamine is a neurotransmitter which is responsible for feelings of pleasure as well as playing a key role in cognition and working memory. When dopamine is released into the brain, it eventually binds with a receptor and is reabsorbed. As a dopamine reuptake inhibitor, caffeine reduces the rate and which dopamine is reabsorbed, causing average dopamine levels to rise. This also has a stimulating effect, and could explain why caffeine increases one's ability to focus.

Like caffeine, studies on theacrine (as Teacrine®) found it to work on both the adenosinergic and dopamineric pathways. [3][4] In a locomotion study on rats, the effect of theacrine on the adenosinergic pathway was established due to theacrine attenuating the decline in locomotion caused by the administration of adenosine antagonists. (Drugs which enhance the effects of adenosine.) [4] The same study also found evidence of theacrine working on the dopaminergic pathway by seeing evidence of concentrated doses activating dopamine receptors D1 and D2. [4]

Try Theacrine Today!

We're proud to be the first company to offer pure Theacrine for sale direct to consumers. If you want the same boost in energy given by coffee, for less than a cup of coffee per dose give theacrine a try today and see if it's right for you. We don't want anyone feeling ripped off, so we provide a complete 100% money back guarantee on your first bottle. No questions asked!

Cited Studies

  1. Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.
  2. Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.
  3. The effects of TeacrineTM, a nature-identical purine alkaloid, on subjective measures of cognitive function, psychometric and hemodynamic indices in healthy humans: a randomized, double-blinded crossover pilot trial
  4. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.
  5. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice.
  6. 1,3,7,9-tetramethyluric acid--a chromosome-damaging agent occurring as a natural metabolite in certain caffeine-producing plants.

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   What Our Customers Say...

Before switching to theacrine I was a coffee addict for years, drinking as many as 4 cups per day. Theacrine provides the same boost, but doesn't stop being effective as quickly as caffeine. Now I don't need coffee to function, and get a nice boost when I do have a cup!

Lisa N

Theacrine is great! I like to take it every other day before I hit the gym. It gives me the boost I need to have great workouts.

James P