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Theacrine Frequently Asked Questions

What is Theacrine?

Theacrine, also known as 1,3,7,9-tetramethyluric acid, is a small purine alkaloid molecule which is very similar to caffeine in both structure and properties.

It is found in the highest concentrations in the kucha variant of camellia assamica, but can also be found in smaller concentrations in many other plants that contain caffeine. When taken as a supplement, theacrine acts similarly to caffeine but has a few key differences most notably, is the fact that a tolerance to its effects develops far slower than a tolerance to caffeine.

What Benefits Does Theacrine Provide?

When taken as a supplement, research has shown that theacrine provides the following benefits:

  • Theacrine (as Teacrine®) provides a boost to mental and physical energy and reduces fatigue. [1][2]
  • Improves concentration and the ability to focus.[1]
  • Improves mood and motivation the exercise. [1]
  • Acts as an anti-inflammatory and analgesic (pain reducing) agent. [3]
  • Is a potent anti-oxidant, and can reduce liver damage by raising liver glutiathione levels. [4]
  • Can potentially offset the health damage posed by chronic stress. [4]
  • At low doses, can act as a sedative and sleep aid. [5]

In addition to the benefits listed above, particularly interesting is that research has shown that a tolerance to Theacrine (as Teacrine®) develops much more slowly than it does to caffeine. [1] Whereas a tolerance to caffeine use develops within only a few days, particpants in one study took theacrine daily for seven days without even a slight tolerance buildup.

How Does Theacrine Work?

Like caffeine, theacrine works by blocking adenosine receptors preventing the molecule adenosine from binding with them. When adenosine binds with a receptor one of its effects to to slow down activity in that cell, thus causing drowsiness. As theacrine binds to more and more adenosine receptors, it prevents adenosine from binding and slowing down activity. This results in the feelings of enhanced mental and physical energy that theacrine provides.

Theacrine has also been shown to act as a dopamine reuptake inhibitor. Dopamine is a neurotransmitter that plays an important role in cognition and memory, as well as being one of the neurotransmitters responsible for feelings of well-being. As a dopamine reuptake inhibitor, theacrine prevents dopamine from being reabsorbed after it is released in the brain, causing overall dopamine levels to rise and improving focus and mood.

Is Using Theacrine Safe?

The research performed on Theacrine (as Teacrine®) suggests that its use is as safe as caffeine. [1] One study in which participants used theacrine at doses ranging from 200 - 400 mg found no adverse side effects and no changes in systemic blood flow. [1] Theacrine as found in kucha tea has been consumed by humans for hundreds of years without issue, although it is found at lower doses in kuch tea than it would generally be consumed at as an energy boosting supplement.

The body of currently available research for Theacrine suggests that it is perfectly safe when used at similar doses as caffeine. There is a lack of studies performed on the health risks of consuming high dose Theacrine, so it is not recommended to use more than 450 mg per day.

Does Theacrine Have Any Side Effects?

When used at dosages of between 200 - 400 mg, one study on humans found no adverse side effects. [1] That said, because of theacrine's similarities to caffeine it is likely that some people may experience some of the classic side effects of stimulants such as nervousness, jitters, and anxiety. These side effects are far more likely to be noticed when theacrine is used at high dosages.

How Should Theacrine be Used?

Theacrine is most commonly used to provide a boost in energy. If being used for that purpose, a dose of 150 - 300 mg is typically sufficient. Theacrine has been studied at doses up to 400 mg and appears to be safe to use in that quantity. It is not recommended that more than 450 mg of Theacrine be used per day however.

Some research also suggests that when used at low doses Theacrine can act as a sedative. [5] If using Theacrine for this purpose, a generally recommended dose is 30 - 50 mg.

How Does Theacrine Differ From Caffeine?

Theacrine is very similar in structure, effects, and safety to caffeine. There are however, a few key differences which potentially make theacrine a superior supplement. First, is the fact that tolerance to caffeine builds much more quickly than to theacrine. (as Teacrine®) [1] A caffeine tolerance can form in as few as three or four days, while studies on theacrine have showed consistent use for over 1 week without any tolerance forming.

Another important difference is that theacrine has been found to have a number of additional health benefits that caffeine does not possess. One study found theacrine to provide both anti-inflammatory and analgesic (pain relieving) effects. [3] Another study found theacrine to be a potent antioxidant that may also help reduce the health consequences of a stressful lifestyle. [4] These are benefits unique to theacrine.

How Do I Know that Theacrine Will Work for Me?

Like caffeine, almost everyone will respond to and notice the benefits of theacrine. While there is a large body of research attesting to theacrine's energy boosting benefits in healthy individuals, we recognize that everyone will have a different opinion on how well it works for them.

For this reason, we offer a full money-back guarantee on your first bottle of Theacrine. If you don’t feel it works for you, let us know and we will immediately provide a full refund.

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Cited Sources

  1. The effects of TeacrineTM, a nature-identical purine alkaloid, on subjective measures of cognitive function, psychometric and hemodynamic indices in healthy humans: a randomized, double-blinded crossover pilot trial
  2. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.
  3. Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.
  4. Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.
  5. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice.

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