Initial research suggests that Theacrine (as Teacrine®) is extremely safe when used at reasonable doses. Just like caffeine, however, it is likely that it can be dangerous when used irressponsibly.
Research has shown that theacrine is safe to use at doses up to 400 mg, but we recommend it be used at doses between 150 - 300 mg as the best balance between effectiveness and side effects has been observed at that dose range.  When used at doses of 200 mg daily for one week, participants in a human trial reported improvements in energy and concentration, and a reduction in fatigue.
Interestingly, this same study found that at doses up to 400 mg there were no side effects present and theacrine had no effect on blood pressure.  That said, while this study found no side effects at these doses, it is very likely that at higher doses some of the classic side effects associated with stimulants such as nervousness, anxiety, and jitters would be seen.
So far, an amount of theacrine needed to cause an overdose in humans has not yet been established. A study in rats found an extremely high LD50 in rats of 810 mg per kg of bodyweight.  This suggests it could be very difficult to overdose, but using LD50 information to decide what dose to take of anything is extremely unwise.
Another study found that theacrine has a similar toxicity profile to caffeine.  While it is typically very difficult to overdose on caffeine, when taken in pill or powder form it becomes much easier. A generally recommended safe dose of caffeine is no more than 400 mg per day, and since theacrine has a similar toxicity profile it is not recommended to take larger doses.
We offer high quality Theacrine (as Teacrine®), tested for purity and contaminants and held to a high standard of quality. The Certificate of Analysis and associated testing results for our current inventory are available here: